Alström Syndrome is a rare, multi-system genetic condition in which progressive vision loss is typically one of the earliest and most consistently recognised features, often noticed well before some of the syndrome’s other findings become apparent. Unlike Bardet-Biedl Syndrome, which follows a rod-cone pattern, Alström Syndrome typically causes a cone-rod dystrophy, meaning central and colour vision are affected relatively early in the disease course.
Ghanaian families are guided through an evaluation that recognises this as a whole-body condition — working alongside existing local care for the syndrome’s other systemic aspects — while concentrating the retinal work-up on the specific pattern of cone-rod involvement that sets Alström Syndrome apart from other inherited dystrophies.
10+
years Experience
years Experience
5000+
Patients treated
Patients treated
100+
Countries served
Countries served
NABH
Guided facility
Guided facility
Ocular Symptoms
Early signs commonly include marked light sensitivity, involuntary rhythmic eye movements (nystagmus), and progressive loss of both central and peripheral vision that typically begins in infancy or the first few years of life — earlier than in most other inherited retinal dystrophies. Because central vision is affected relatively early, difficulty with fine detailed tasks and colour discrimination is often reported alongside the broader decline in vision.
Underlying Causes
Alström Syndrome is caused by mutations in the ALMS1 gene, inherited in an autosomal recessive pattern. ALMS1 plays a role in the function of cilia across multiple organ systems, which is why the retina — among the tissues most dependent on properly functioning cilia — is typically one of the earliest and most consistently affected.
Diagnosis for Ghanaian Patients
The retinal work-up includes electroretinography, OCT imaging, and visual field testing, with particular attention paid to the ERG pattern of cone involvement preceding or matching rod involvement, which helps confirm a cone-rod rather than rod-cone classification. Genetic confirmation of ALMS1 mutations supports the diagnosis and helps tell Alström Syndrome apart from other syndromic and non-syndromic retinal dystrophies with overlapping early features.
Meet The Team
Our Eye Specialists
Dr. Pawan
Associate Professor, Vitreo-Retina Surgeon. 10+ Years Experience
Retinal disorders, diabetic retinopathy, and advanced retina procedures. Provides diagnostic evaluation and treatment planning for international patients.
Dr.Pallavee
Senior Consultant Ophthalmologist & Eye Surgeon· 26+ yrs experience
Areas of Focus: Cataract surgery, corneal disorders, refractive procedures, and glaucoma management. Provides comprehensive eye care and surgical expertise for global patients.
Dr. Robin
Consultant Ophthalmologist & Eye Surgeon, MD, DO .16+ Years Experience
Areas of Focus: Cataract surgery, corneal disorders, refractive procedures, and glaucoma management. Provides comprehensive eye care and surgical expertise for global patients.
Treatment Approach in India
Given how early visual symptoms typically appear, the retinal care plan for Alström Syndrome places particular emphasis on timely evaluation for stem cell therapy in eligible patients and on early low-vision strategies suited to a young child, alongside coordination with the family’s existing care for the syndrome’s other systemic features.
Reviews
What Our Patients Say
DR NAAGALAKSHMI R
1 week ago
Asha Babbar
2 weeks ago
The overall experience at the RP Treatment Center was very good. The staff was supportive and caring, and we provided proper attention and guidance during treatment. The environment at the center was clean and comfortable. The doctors and staff tried to understand patients' needs and explained the treatment process well.
Overall, I am satisfied with the service and care. Highly recommended!
Overall, I am satisfied with the service and care. Highly recommended!
Harshita Kapoor
2 weeks ago
Life‑Changing Experience with RP Therapy”
After years of struggling with vision loss due to Retinitis Pigmentosa, I finally found hope here. The doctors were highly professional, explained the stem cell treatment in detail, and gave me confidence at every step. The therapy was smooth, and I’ve already noticed positive changes in my daily life. Their dedication, care, and advanced medical approach make this center truly trustworthy
After years of struggling with vision loss due to Retinitis Pigmentosa, I finally found hope here. The doctors were highly professional, explained the stem cell treatment in detail, and gave me confidence at every step. The therapy was smooth, and I’ve already noticed positive changes in my daily life. Their dedication, care, and advanced medical approach make this center truly trustworthy
Yash Chauhan
2 weeks ago
I had a really good experience at RP Treatment Centre. The doctor listened to my problem patiently and explained the treatment in a simple way. The staff was polite and the clinic was clean. I started feeling better after the treatment. Highly recommended!
pragya chauhan
2 weeks ago
Very satisfied with the service. The doctor is experienced and gives proper attention to every patient. The staff is friendly, and the overall environment is comfortable. Thank you, RP Treatment Centre, for the excellent care.
Manisha kapoor
2 weeks ago
I had been struggling with Retinitis Pigmentosa for years, and finding this center was truly life‑changing. The doctors provided a thorough medical evaluation and explained every step of the stem cell therapy process with clarity. The treatment was smooth, professional, and I noticed encouraging improvements in my vision within weeks. Their continuous follow‑up care and compassionate support made me feel confident throughout the journey. Highly recommended for anyone seeking advanced RP treatment in India.
Frequently Asked Questions
Why does my child’s vision loss seem to affect central vision earlier than what I’ve read about other retinal conditions?
“This is a recognised pattern specific to Alström Syndrome — it typically follows a cone-rod course, meaning central and colour vision are affected relatively early, unlike the more common rod-first pattern seen in classic retinitis pigmentosa.”
Is Alström Syndrome the same as Bardet-Biedl Syndrome?
”
They are different conditions with some overlapping systemic features, but they arise from different genes and follow different retinal patterns — Alström typically affects central vision earlier (cone-rod), while Bardet-Biedl more often follows the rod-first pattern typical of classic RP. Genetic testing distinguishes between the two.”
Should we be concerned about other organs, given this is a multi-system condition?
“Alström Syndrome can involve other systems including hearing, heart, and metabolic function, so ongoing coordination with the relevant specialists managing those aspects locally in Ghana remains important alongside the retinal evaluation we provide.”
How early is too early to bring a child with suspected Alström Syndrome for retinal evaluation?
“Given how early visual symptoms tend to appear in this condition, there’s generally no benefit to waiting — an early baseline assessment helps establish the starting point against which any future changes can be measured.”
